To emphasize something in italics enclose it between <em> and </em>. For example
  To be or <em>not to be</em>, that is the question:
gives you
To be or not to be, that is the question:
To emphasize something in bold enclose it between <b> and </b>. For example
  To be or <b>not to be</b>, that is the question:
gives you
To be or not to be, that is the question:
You can combine the two effects. For example
  To be or <b><em>not to be</em></b>, that is the question:
gives you
To be or not to be, that is the question: